UCSF Researchers Rescue Cognitive Function by Blocking Molecular Stress Response with ISRIBA small molecule called ISRIB that was identified at UCSF can reverse the neuronal and cognitive effects of concussion in mice weeks after an injury occurred, new research found.
Diverse Digital Interventions Remediate Cognitive Aging in Healthy Older AdultsAfter a decade of work, scientists at UCSF’s Neuroscape Center have developed a suite of video game interventions that improve key aspects of cognition in aging adults.
Treatment Depends on Amyloid Plaques, but UCSF-Vanderbilt Led Study Shows Lower Incidence in MinoritiesA new study shows that fewer Black, Hispanic and Asian patients would qualify for these treatments that may slow Alzheimer’s progression, since cognitive impairment in these groups is more likely to be caused by other forms of dementia that may be unrelated to amyloid plaques.
New Molecules Are Lead Candidates for Alternative to Narcotics, Say UCSF ResearchersA newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
Findings Open Door to Precision Therapeutics for Neonatal HemorrhageUCSF has revealed how blood vessel cells develop in the prenatal human brain, paving the way to fully understand the role of these cells in healthy brain development and disease.
Designer Molecules Activate Select Pathway of the Psychedelic Receptor 5HT2aScientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.
UCSF-Led Study Suggests Model May Lead to Fewer Unnecessary Medical InterventionsA mortality prediction model for older adults with dementia may help physicians determine which treatments to provide while facilitating decision-making for patients and their families.
Bacterial Populations Can Change with Widely Used MS TreatmentResearchers have found significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, showing new pathways for potential treatment.
Research Describes a “Health Shock” from Losing Housing Later in LifeThe study, funded by the National Institute on Aging, recruited people who were 50 and older and homeless, and followed them for a median of 4.5 years. By interviewing people every six months about their health and housing status, researchers were able to examine how things like regaining housing, using drugs, and having various chronic conditions, such as diabetes, affected their risk of dying.
Multiple Brain Regions Coordinate to Conjure Wholly Imagined WorldsWhen our eyes move during REM sleep, we’re gazing at things in the dream world our brains have created, according to a new study by UCSF researchers. The findings shed light not only into how we dream, but also into how our imaginations work.